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RT-qPCR was performed with the Luna Universal qPCR Master Mix (New England BioLabs) using the primers listed in ( Supplementary Table 4 )

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(If the test cannot be completed temporarily, the supernatant can be stored at -80 for 10 days.) Blood sample Plasma: Sample is centrifuged at 600 g for 10 minutes at 4

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Most patients are advised 8 to 10 sessions and each session is held after an interval of a few weeks